Effects of Periodized Circuit Training Versus Conventional Strength Training on Cardio metabolic and Pulmonary Outcomes in Type 2 Diabetes Mellitus: A Randomized Controlled Trial

Cardio-metabolic Adaptations to Exercise in T2DM

Authors

  • Dr. Hina Javed Riphah International University Lahore, Pakistan
  • Dr. Hafiza Muriam Ghani Riphah International University Lahore, Pakistan
  • Dr. Shoaib Memon Shaheed Benazir Bhutto Dewan University
  • Dr. M Usman Shaheed Benazir Bhutto Dewan University
  • Dr. Toufail Ahmad Sarhad University of Science and Information Technology
  • Dr. Sawaira Khatoon Abro Jinnah Ppostgradute Medical Centre

Keywords:

Exercise Therapy, Glycated Hemoglobin A, Pulmonary Function Tests, Resistance Training, Type-2 Diabetes Mellitus

Abstract

Background: Type 2 diabetes mellitus (T2DM) is associated with poor cardiovascular and metabolic outcomes. Although periodized circuit training (PCT) and conventional strength training (CST) are both recommended in the management of T2DM, the relative effectiveness of each training method across these multidimensional outcomes has not been clearly defined. Therefore, this study aimed to determine the effects of a 12-week PCT program with CST on pulmonary function, cardiovascular fitness, glycemic control, and Health related Quality of Life (HRQoL) in adults with T2DM.

Methods: Fifty adults with T2DM were randomly allocated to a PCT group (Group A, n=25) or a CST group (Group B, n=25) in a single-blind randomized controlled trial conducted at JPMC Hospital, Karachi. Both groups performed home-based training 3 times/week for 45-minute over 12 weeks. The baseline and post-intervention outcomes included FVC, FEV1, FEV1/FVC ratio, PEFR, six-minute walk test (6MWT) distance, HRQoL (SF-36), and HbA1c. Wilcoxon Signed-Rank and Mann–Whitney U were used for analysis.

Results: Both groups demonstrated important within-group improvement of most outcomes (p < 0.05). Between group analysis showed that there were no significant differences in FVC, FEV1, PEFR, 6MWT, HRQoL or HbA1c. Nevertheless, the FEV1/FVC ratio increased significantly in the PCT group compared to the CST group (83.52 ± 3.42% vs. 81.52 ± 2.85%; U=202.5, p=0.032), which is indicative of better airway efficiency.

Conclusion: Both PCT and CST are effective home-based interventions to improve pulmonary function, cardiovascular fitness, glycemic control and quality of life in T2DM patients. PCT demonstrated greater improvements in airway efficiency, suggesting broader pulmonary benefits.

DOI: https://doi.org/10.59564/amrj/04.02/002

 

Author Biographies

Dr. Hina Javed, Riphah International University Lahore, Pakistan

Physical Therapist

Dr. Hafiza Muriam Ghani, Riphah International University Lahore, Pakistan

Senior Lecturer 

Dr. Shoaib Memon, Shaheed Benazir Bhutto Dewan University

Physical Therapist

Dr. M Usman, Shaheed Benazir Bhutto Dewan University

Physical Therapist

Dr. Toufail Ahmad, Sarhad University of Science and Information Technology

Physical Therapist

Dr. Sawaira Khatoon Abro, Jinnah Ppostgradute Medical Centre

Physical Therapist

References

Duncan BB, Magliano DJ, Boyko EJ. IDF diabetes atlas 11th edition 2025: global prevalence and projections for 2050. Nephrol Dial Transplant. 2026 Jan;41(1):7–9. doi: 10.1093/ndt/gfaf177

Genitsaridi I, Salpea P, Salim A, Sajjadi SF, Tomic D, James S, Thirunavukkarasu S, Issaka A, Chen L, Basit A, Luk AO. 11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050

Lancet Diabetes Endocrinol. 2026 Feb;14(2):149–56. doi: 10.1016/S2213-8587(25)00299-2

Goyal R, Singhal M, Jialal I. Type 2 diabetes. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 [updated 2023 Jun 23]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513253/

Díez-Manglano J, Asin Samper U. Pulmonary function tests in type 2 diabetes: a meta-analysis. ERJ Open Res. 2021 Jan;7(1):00371-2020. doi: 10.1183/23120541.00371-2020

Jing X, Chen J, Dong Y, Han D, Zhao H, Wang X, Gao F, Li C, Cui Z, Liu Y, Ma J. Related factors of quality of life of type 2 diabetes patients: a systematic review and meta-analysis. Health Qual Life Outcomes. 2018 Sep 19;16(1):189. doi: 10.1186/s12955-018-1021-9

Kanaley JA, Colberg SR, Corcoran MH, Malin SK, Rodriguez NR, Crespo CJ, Kirwan JP, Zierath JR. Exercise/physical activity in individuals with type 2 diabetes: a consensus statement from the American College of Sports Medicine. Med Sci Sports Exerc. 2022 Feb;54(2):353–68. doi: 10.1249/MSS.0000000000002800

Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, Horton ES, Castorino K, Tate DF. Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2016 Nov;39(11):2065–79. doi: 10.2337/dc16-1728

Karstoft K, Pedersen BK. Exercise and type 2 diabetes: focus on metabolism and inflammation. Immunol Cell Biol. 2016 Feb;94(2):146–50. doi: 10.1038/icb.2015.101

Umpierre D, Ribeiro PA, Kramer CK, Leitao CB, Zucatti AT, Azevedo MJ, Gross JL, Ribeiro JP, Schaan BD. Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. JAMA. 2011 May 4;305(17):1790–9. doi: 10.1001/jama.2011.576

Sabag A, Chang CR, Francois ME, Keating SE, Coombes JS, Johnson NA, Pastor-Valero M, Lopez JP. The effect of exercise on quality of life in type 2 diabetes: a systematic review and meta-analysis. Med Sci Sports Exerc. 2023 Aug;55(8):1353–65. doi: 10.1249/MSS.0000000000003172

Ahmad E, Lim S, Lamptey R, Webb DR, Davies MJ. Type 2 diabetes. Lancet. 2022 Nov 19;400(10365):1803–20. doi: 10.1016/S0140-6736(22)01655-5

George M, Zilbermint M, Sokolinsky S, Batty K, Motevalli M, Stanback C, Gonzales E, Miller C, Sequeira L, Demidowich AP. Effects of preprandial versus postprandial nutritional insulin administration in the inpatient setting. Diabetes Res Clin Pract. 2024 Aug;214:111785. doi: 10.1016/j.diabres.2024.111785

Al-Mhanna SB, Batrakoulis A, Ghazali WS, Mohamed M, Aldayel A, Alhussain MH, Afolabi HA, Wada Y, Gülü M, Elkholi S, Abubakar BD. Effects of combined aerobic and resistance training on glycemic control, blood pressure, inflammation, cardiorespiratory fitness and quality of life in patients with type 2 diabetes and overweight/obesity: a systematic review and meta-analysis. PeerJ. 2024 Jun 14;12:e17525. doi: 10.7717/peerj.17525

Grgic J, Schoenfeld BJ, Davies TB, Lazinica B, Krieger JW, Pedisic Z. Effect of resistance training frequency on gains in muscular strength: a systematic review and meta-analysis. Sports Med. 2018 May;48(5):1207–20. doi: 10.1007/s40279-018-0872-x

Magni O, Arnaoutis G, Panagiotakos D. The impact of exercise on chronic systemic inflammation: a systematic review and meta–meta-analysis. Sport Sci Health. 2025 Sep;21(3):1405–17. doi: 10.1007/s11332-025-01445-3

Machado I, Ferreira J, Magalhães C, Sousa P, Dias L, Santarém D, Moreira H, Abrantes C. Six-month combined aerobic and resistance exercise program enhances 6-minute walk test and physical fitness in people with peripheral arterial disease: a pilot study. J Vasc Nurs. 2024 Sep;42(3):145–53. doi: 10.1016/j.jvn.2024.03.002

Kammin EJ. The 6-minute walk test: indications and guidelines for use in outpatient practices. J Nurse Pract. 2022 Jun;18(6):608–10. doi: 10.1016/j.nurpra.2022.04.013

Graham BL, Steenbruggen I, Miller MR, Barjaktarevic IZ, Cooper BG, Hall GL, Hallstrand TS, Kaminsky DA, McCarthy K, McCormack MC, Oropez CE. Standardization of spirometry 2019 update: an official American Thoracic Society and European Respiratory Society technical statement. Am J Respir Crit Care Med. 2019 Oct 15;200(8):e70–88. doi: 10.1164/rccm.201908-1590ST

Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473–83.

Wrench E, Subar DA, Bampouras TM, Lauder RM, Gaffney CJ. Myths and methodologies: assessing glycaemic control and associated regulatory mechanisms in human physiology research. Exp Physiol. 2024 Sep;109(9):1461–77. doi: 10.1113/EP091433

Afshonpour MT, Ghalavand A, Rezaei R, Habibi A. The effect of exercise training on pulmonary function indices in men with type 2 diabetes. J Alborz Univ Med Sci. 2015 Nov;4(4):255–65. doi: 10.18869/acadpub.aums.4.4.255

Tayebi SM, Poorhabibi H, Heidary D, Amini MA, Sadeghi A. Impact of aerobic exercise on chronic inflammation in older adults: a systematic review and meta-analysis. BMC Sports Sci Med Rehabil. 2025 Aug 8;17(1):229. doi: 10.1186/s13102-025-01279-z

Khosravi M, Tayebi SM, Safari H. Single and concurrent effects of endurance and resistance training on pulmonary function. Iran J Basic Med Sci. 2013 Apr;16(4):628–34.

Pesta DH, Goncalves RL, Madiraju AK, Strasser B, Sparks LM. Resistance training to improve type 2 diabetes: working toward a prescription for the future. Nutr Metab (Lond). 2017 Mar 14;14(1):24. doi: 10.1186/s12986-017-0173-7

Spaulding HR, Yan Z. AMPK and the adaptation to exercise. Annu Rev Physiol. 2022 Feb 10;84:209–27. doi: 10.1146/annurev-physiol-060721-095517

Soo J, Raman A, Lawler NG, Goods PS, Deldicque L, Girard O, Fairchild TJ. The role of exercise and hypoxia on glucose transport and regulation. Eur J Appl Physiol. 2023 Jun;123(6):1147–65. doi: 10.1007/s00421-023-05135-1

Bright FM, Clark B, Jay O, Periard JD. Influence of air velocity on self-paced exercise performance in hot conditions. Med Sci Sports Exerc. 2023 Aug;55(8):1382–91. doi: 10.1249/MSS.0000000000003168

Downloads

Published

2026-04-30