Prevalence of Chronic Kidney Disease in Patients with Diabetes and Hypertension: A Cross-Sectional Study
CKD Prevalence in Diabetes and Hypertension
Keywords:
Chronic kidney disease, Diabetes mellitus, Hypertension, PrevalenceAbstract
Background: Chronic kidney disease (CKD) arises from a GFR lesser than 60 ml/min/1.73 m². Diabetes and hypertension together put an individual at significant risk of CKD. The early detection of CKD is a primary preventive measure for kidney disease and its future complications. Hence, creating an awareness campaign and providing sustainable means for early detection of kidney disease are significant hits on the public health agenda. The study aimed to determine CKD prevalence in patients with Diabetes Mellitus and hypertension.
Methods: The multi-centric study was conducted from October 2023 to August 2024. The cross-sectional study covered 322 patients selected through convenience sampling. A health camp was established at the hospital site to facilitate the smooth handling of data collection. Patients with an age of >40 years with diagnosed cases of diabetes mellitus and/or hypertension, CKD, and with GFR report were recruited into the study. Variables were analyzed and processed through SPSS software version 22.0. Data entry and analysis were performed using SPSS software version 22.0. A p-value of <0.05 is considered statistically significant.
Results: The mean age of the participants was 62.10±11.57. Of them, 265 (58.0%) were males, and 192 (42.0%) were females. The prevalence of CKD among patients with diabetes mellitus was noted to be standing at 31.94%, whereas it was reported at 55.79% for hypertension.
Conclusion: Our study demonstrates a substantial prevalence of CKD among patients with diabetes and hypertension, with many of them having moderate-to-severe renal dysfunction.
References
Gupta R, Woo K, Jeniann AY. Epidemiology of end-stage kidney disease. InSeminars in vascular surgery. 2021 Mar 1;34(1):71-78. WB Saunders. DOI: http://doi.org/10.1053/j.semvascsurg.2021.02.010
Liyanage T, Toyama T, Hockham C, Ninomiya T, Perkovic V, Woodward M, Fukagawa M, Matsushita K, Praditpornsilpa K, Hooi LS, Iseki K. Prevalence of chronic kidney disease in Asia: a systematic review and analysis. BMJ Global Health. 2022 Jan 1;7(1):e007525.
Ameer OZ. Hypertension in chronic kidney disease: What lies behind the scene. Frontiers in Pharmacology. 2022 Oct 11;13:949260. DOI: http://doi.org/10.3389/fphar.2022.949260
Hahr AJ, Molitch ME. Management of diabetes mellitus in patients with CKD: core curriculum 2022. American Journal of Kidney Diseases. 2022 May 1;79(5):728-36.
US National Institute of Diabetes and Digestive and Kidney Diseases. Kidney disease statistics for the United States. Available at: https://www.niddk.nih.gov/health-information/health-statistics/kidney-disease (2023).
Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, Zhao MH, Lv J, Garg AX, Knight J, Rodgers A. Worldwide access to treatment for end-stage kidney disease: a systematic review. The Lancet. 2015 May 16;385(9981):1975-82.
Anderson E, Durstine JL. Physical activity, exercise, and chronic diseases: A brief review. Sports Medicine and Health Science. 2019 Dec 1;1(1):3-10.
Ng MS, Charu V, Johnson DW, O’Shaughnessy MM, Mallett AJ. National and international kidney failure registries: characteristics, commonalities, and contrasts. Kidney International. 2022 Jan 1;101(1):23-35.
Pollock C, Moon JY, Gojaseni P, Ching CH, Gomez L, Chan TM, Wu MJ, Yeo SC, Nugroho P, Bhalla AK. Framework of guidelines for management of CKD in Asia. Kidney International Reports. 2024 Apr 1;9(4):752-90. DOI: http://doi.org/10.1016/j.ekir.2023.12.010
Trends in prevalence of CKD among U.S. adults with hypertension (no date). Kidney Disease Surveillance System. Available at: https://nccd.cdc.gov/ckd/detail.aspx?Qnum=Q764&topic=4#:~:text=Crude%20prevalence%20of%20chronic%20kidney,from%202001%20through%20March%202020.
Samsu N. Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. BioMed Research International. 2021;2021(1):1497449. DOI: http://doi.org/10.1155/2021/1497449
Gheith O, Farouk N, Nampoory N, Halim MA, Al-Otaibi T. Diabetic kidney disease: worldwide difference of prevalence and risk factors. Journal of Nephropharmacology. 2015 Oct 9;5(1):49.
International Diabetes Federation. Diabetes Atlas 10th edn. Available at: https://diabetesatlas.org/en/resources.
Fenta ET, Eshetu HB, Kebede N, Bogale EK, Zewdie A, Kassie TD, Anagaw TF, Mazengia EM, Gelaw SS. Prevalence and predictors of chronic kidney disease among type 2 diabetic patients worldwide, systematic review and meta-analysis. Diabetology & Metabolic Syndrome. 2023 Nov 28;15(1):245. DOI: http://doi.org/10.1186/s13098-023-01202-x
Teo BW, Chan GC, Leo CC, Tay JC, Chia YC, Siddique S, Turana Y, Chen CH, Cheng HM, Hoshide S, Minh HV. Hypertension and chronic kidney disease in Asian populations. The Journal of Clinical Hypertension. 2021 Mar;23(3):475-80. DOI: http://doi.org/10.1111/jch.13714
Chen TK, Knicely DH, Grams ME. Chronic kidney disease diagnosis and management: a review. JAMA. 2019 Oct 1;322(13):1294-304. DOI: http://doi.org/10.1001/jama.2019.14745
Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. The Lancet. 2021 Aug 28;398(10302):786-802.
Ahmed J, Azhar S, ul Haq N, Hussain S, Stájer A, Urbán E, Gajdács M, Jamshed S. Awareness of chronic kidney disease, medication, and laboratory investigation among nephrology and urology patients of Quetta, Pakistan. International Journal of Environmental Research and Public Health. 2022 Apr 20;19(9):5015. DOI:http://doi.org/10.3390/ijerph19095015
Alghamdi A, Alaryni A, AlMatham K, Hakami O, Qutob R, Bukhari A, Abualnaja A, Aldosari Y, Altamimi N, Alshahrani K, Alsabty A. Knowledge, attitudes, and practices of high-risk patients towards prevention and early detection of chronic kidney disease (CKD) in Saudi Arabia. International Journal of Environmental Research and Public Health. 2023 Jan 3;20(1):871. DOI: http://doi.org/10.3390/ijerph20010871
Hebert SA, Ibrahim HN. Hypertension management in patients with chronic kidney disease. Methodist DeBakey Cardiovascular Journal. 2022;18(4):41. DOI: http://doi.org/10.14797/mdcvj.1119
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