Effects of Vitamin D Supplementation on Omentin-1, Leptin, and Lipid Profile in Patients with Coronary Artery Disease: Vitamin D Supplementation in Coronary Artery Disease

Shazia  Nazar; Syeda Hina Abbas; Syeda Sana  Abbas

Authors

Shazia Nazar Dow University of Health Sciences, Karachi, Pakistan
Hina Abbas Dow University of Health Sciences, Karachi, Pakistan
Sana Abbas Abbasi Shaheed Hospital, Karachi, Pakistan

Keywords:

Adipokines, Biomarkers, Coronary artery disease, Vitamin D, Lipid metabolism

Abstract

Background: Vitamin D has drawn impressive interest because of its significance in various extra-skeletal illnesses, including multiple sclerosis, malignancies, diabetes mellitus, and cardiovascular disease. Vitamin D exhibits anti-inflammatory properties, too, yet the role of vitamin D supplementation in decreasing inflammatory biomarkers remains generally obscure. This study aimed to evaluate the effects of oral vitamin-D intake on lipid profile, anthropometric indices and plasma levels of adipokines, including leptin and omentin-1, in patients with coronary artery disease (CAD).

Methods: This study was conducted at the Cardiac Units Civil Hospital in Karachi, Pakistan from January to December 2023. A total of 200 diagnosed patients with coronary artery disease who had already been prescribed oral vitamin D due to insufficient vitamins were included in the study. Their health care consultants prescribed patients a daily dose of 2000IU vitamin D for 8 weeks. Lipid profile, anthropometric measurements and serum levels of vitamin D, omentin-1 and leptin were assessed at the beginning and end of the study.

Results: Vitamin-D supplementation led to a notable decrease in leptin concentration (3776±0.422 vs. 3187±0.144, p<0.001). Moreover, circulating omentin-1 levels (245±26.1 vs. 296.5±28.11, p<0.001) and HDL-cholesterol levels (36.80±13.46 vs. 45.2±14.31, p< 0.001) were found significantly higher at the end of study.

Conclusion: This study demonstrated that an 8 week vitamin D supplementation in CAD patients significantly reduced leptin levels while increasing omentin-1 and HDL-c levels, suggesting their potential cardioprotective effects.

DOI: https://doi.org/10.59564/amrj/03.02/004

Author Biographies

Shazia Nazar , Dow University of Health Sciences, Karachi, Pakistan

Associate Professor, Department of Physiology

Hina Abbas, Dow University of Health Sciences, Karachi, Pakistan

Assistant Professor, Department of Pathology

Sana Abbas, Abbasi Shaheed Hospital, Karachi, Pakistan

Senior Registrar, Department of Pediatrics

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