Effects of Exercise on Cartilage Thickness and Chondrocytes Count: A Meta-Analysis of Pre-Clinical Randomized Controlled Trials Conducted on Rats
Exercise and Cartilage Health
Keywords:
Exercises, Cartilage, Chondrocytes, Animal Physical ConditioningAbstract
Background: The evidence regarding the effects of exercises on cartilage is enormous, literature on improving cartilage thickness and chondrocytes number is limited. To determine the cumulative effects of exercises on cartilage thickness and chondrocytes number by combining results from different randomized controlled trials.
Methods: Using MeSH terms like "cartilage thicknesses", "exercises", "chondrocytes", and "physical training", among others, multiple searches are conducted on exercise-based management approaches on cartilage thicknesses using search engines like Google Scholar, PEDro, MEDLINE, Cochrane Library, EMBASE, and Web of Science.
Results: The risk of bias assessment was performed based on the guidelines of SYRCLE. The author-based judgment was performed on selection, performance, detection, attrition, reporting, and other biases. The quantitative analysis revealed that femoral cartilage thickness had increased in the exercise group (SMD=1.039, CI%= -0.64 to 2.72, p=0.225) while chondrocyte count had shown a mild increase in response to excises (SMD= -0.147, CI%= -2.161 to 1.866, p=0.883).
Conclusion: It has concluded that although exercises have a potential impact on cartilage morphology but it must be performed within adaptive threshold limits.
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Copyright (c) 2024 Kiran Yameen, Kevin Joseph Jerome Borges, Amna Aamir Khan, Syed Nudrat Nawaid Shah
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