Effects of Exercise on Cartilage Thickness and Chondrocytes Count: A Meta-Analysis of Pre-Clinical Randomized Controlled Trials Conducted on Rats

Exercise and Cartilage Health

Authors

  • Kiran Yameen Ziauddin University
  • Dr. Kevin Joseph Jerome Borges Ziauddin University
  • Dr. Amna Aamir Khan Ziauddin University
  • Dr. Syed Nudrat Nawaid Shah Ziauddin University

Keywords:

Exercises, Cartilage, Chondrocytes, Animal Physical Conditioning

Abstract

Background: The evidence regarding the effects of exercises on cartilage is enormous, literature on improving cartilage thickness and chondrocytes number is limited. To determine the cumulative effects of exercises on cartilage thickness and chondrocytes number by combining results from different randomized controlled trials.

Methods: Using MeSH terms like "cartilage thicknesses", "exercises", "chondrocytes", and "physical training", among others, multiple searches are conducted on exercise-based management approaches on cartilage thicknesses using search engines like Google Scholar, PEDro, MEDLINE, Cochrane Library, EMBASE, and Web of Science.

Results: The risk of bias assessment was performed based on the guidelines of SYRCLE. The author-based judgment was performed on selection, performance, detection, attrition, reporting, and other biases. The quantitative analysis revealed that femoral cartilage thickness had increased in the exercise group (SMD=1.039, CI%= -0.64 to 2.72, p=0.225) while chondrocyte count had shown a mild increase in response to excises (SMD= -0.147, CI%= -2.161 to 1.866, p=0.883).

Conclusion: It has concluded that although exercises have a potential impact on cartilage morphology but it must be performed within adaptive threshold limits.

Author Biographies

Kiran Yameen, Ziauddin University

College of Physical Therapy, Faculty of Allied Health Sciences

Dr. Kevin Joseph Jerome Borges, Ziauddin University

Professor, Department of Neuroanatomy, Ziauddin Medical College

Dr. Amna Aamir Khan, Ziauddin University

Associate Professor, College of Physical Therapy, Faculty of Allied Health Sciences

Dr. Syed Nudrat Nawaid Shah, Ziauddin University

Associate Professor, Department of Anatomy, Ziauddin Medical College

References

Long Z, Zhang X, Li C, Niu J, Wu X, Li Z. Segmentation and classification of knee joint ultrasonic image via deep learning. Applied Soft Computing. 2020 Dec 1;97:106765.

Gray HA, Guan S, Thomeer LT, Schache AG, de Steiger R, Pandy MG. Three‐dimensional motion of the knee‐joint complex during normal walking revealed by mobile biplane x‐ray imaging. Journal of Orthopaedic Research®. 2019 Mar;37(3):615-30.

Abid M, Mezghani N, Mitiche A. Knee joint biomechanical gait data classification for knee pathology assessment: a literature review. Applied bionics and biomechanics. 2019 May 14;2019.

Andrews SH, Adesida AB, Abusara Z, Shrive NG. Current concepts on structure–function relationships in the menisci. Connective Tissue Research. 2017 May 4;58(3-4):271-81.

Melrose J. The importance of the knee joint meniscal fibrocartilages as stabilizing weight bearing structures providing global protection to human knee-joint tissues. Cells. 2019 Apr 6;8(4):324.

Cook JL, Kuroki K, Stoker AM, Monibi FA, Roller BL. Meniscal biology in health and disease. Connective Tissue Research. 2017 May 4;58(3-4):225-37.

Iseki T, Rothrauff BB, Kihara S, Sasaki H, Yoshiya S, Fu FH, Tuan RS, Gottardi R. Dynamic compressive loading improves cartilage repair in an in vitro model of microfracture: comparison of 2 mechanical loading regimens on simulated microfracture based on fibrin gel scaffolds encapsulating connective tissue progenitor cells. The American journal of sports medicine. 2019 Jul;47(9):2188-99.

Charlier E, Deroyer C, Ciregia F, Malaise O, Neuville S, Plener Z, Malaise M, de Seny D. Chondrocyte dedifferentiation and osteoarthritis (OA). Biochemical pharmacology. 2019 Jul 1;165:49-65.

Marconi D, Sands AK. Biomechanics of Hindfoot Fusions. InFoot and Ankle Biomechanics 2023 Jan 1 (pp. 701-719). Academic Press.

Malekipour F, Lee PV. Shock absorbing ability in healthy and damaged cartilage-bone under high-rate compression. Journal of the Mechanical Behavior of Biomedical Materials. 2019 Feb 1;90:388-94.

Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS. Decorin regulates the aggrecan network integrity and biomechanical functions of cartilage extracellular matrix. ACS nano. 2019 Sep 24;13(10):11320-33.

Zhou Z, Cui J, Wu S, Geng Z, Su J. Silk fibroin-based biomaterials for cartilage/osteochondral repair. Theranostics. 2022;12(11):5103.

Vedadghavami A, Wagner EK, Mehta S, He T, Zhang C, Bajpayee AG. Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues. Acta biomaterialia. 2019 Jul 15;93:258-69.

DeFrate LE, Kim-Wang SY, Englander ZA, McNulty AL. Osteoarthritis year in review 2018: mechanics. Osteoarthritis and cartilage. 2019 Mar 1;27(3):392-400.

Bielajew BJ, Hu JC, Athanasiou KA. Collagen: quantification, biomechanics and role of minor subtypes in cartilage. Nature Reviews Materials. 2020 Oct;5(10):730-47.

Armiento AR, Alini M, Stoddart MJ. Articular fibrocartilage-Why does hyaline cartilage fail to repair?. Advanced drug delivery reviews. 2019 Jun 1;146:289-305.

Komarraju A, Goldberg-Stein S, Pederson R, McCrum C, Chhabra A. Spectrum of common and uncommon causes of knee joint hyaline cartilage degeneration and their key imaging features. European Journal of Radiology. 2020 Aug 1;129:109097.

Oláh T, Goyal DR, Madry H. The illustrative anatomy and the histology of the degenerative hyaline cartilage. The Illustrative Book of Cartilage Repair. 2021:11-9.

Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS. Decorin regulates the aggrecan network integrity and biomechanical functions of cartilage extracellular matrix. ACS nano. 2019 Sep 24;13(10):11320-33.

Krishnan Y, Grodzinsky AJ. Cartilage diseases. Matrix Biology. 2018 Oct 1;71:51-69.

Bricca A, Juhl CB, Steultjens M, Wirth W, Roos EM. Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials. British journal of sports medicine. 2019 Aug 1;53(15):940-7.

Bricca A, Struglics A, Larsson S, Steultjens M, Juhl CB, Roos EM. Impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in individuals at risk of, or with established, knee osteoarthritis: a systematic review and meta‐analysis of randomized controlled trials. Arthritis care & research. 2019 Nov;71(11):1504-15.

Hooijmans CR, Rovers MM, De Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE’s risk of bias tool for animal studies. BMC medical research methodology. 2014 Dec;14:1-9.

Zhu X, Liu Q, Cao M, Feng ZT. Reporting Quality and Risk of Bias Assessment of Animal Research on Chaihu-Shugan-San for Depression: A Systematic Review. Available at SSRN 4297917.

Schober P, Mascha EJ, Vetter TR. Statistics from A (agreement) to Z (z score): a guide to interpreting common measures of association, agreement, diagnostic accuracy, effect size, heterogeneity, and reliability in medical research. Anesthesia & Analgesia. 2021 Nov 15;133(6):1633-41.

Neves M, de Freitas Tavares AL, Retameiro AC, Reginato A, da Silva Leal TS, Ribeiro LD, Bertolini GR. Morphometric aspects of the articular cartilage of rats treated with low-level laser therapy and exercise in a rheumatoid arthritis model. ABCS Health Sciences. 2022 Oct 25;47:e022223-.

Zhou L. O METABOLISMO CELULAR SOB EXERCÍCIOS DE DIFERENTES INTENSIDADES NA MEDICINA DO ESPORTE. Revista Brasileira de Medicina do Esporte. 2021 Dec 3;27:682-5.

Naeini RM, Sahebozamani M, Nazem MN. Effect of running on inclined treadmill on the occurrence of knee joint osteoarthritis in the male and female Wistar rats. Zahedan Journal of Research in Medical Sciences. 2018 Apr;20(4).

Qian J, Liang J, Wang Y, Wang H. Effect of passive motion on articular cartilage in rat osteoarthritis. Experimental and therapeutic medicine. 2014 Aug 1;8(2):377-83.

Ni GX, Liu SY, Lei L, Li Z, Zhou YZ, Zhan LQ. Intensity-dependent effect of treadmill running on knee articular cartilage in a rat model. BioMed Research International. 2013 Oct;2013.

Metsios GS, Moe RH, Van Der Esch M, van Zanten JV, Fenton SA, Koutedakis Y, Vitalis P, Kennedy N, Brodin N, Bostrom C, Swinnen TW. The effects of exercise on cardiovascular disease risk factors and cardiovascular physiology in rheumatoid arthritis. Rheumatology international. 2020 Mar;40(3):347-57.

Luan X, Tian X, Zhang H, Huang R, Li N, Chen P, Wang R. Exercise as a prescription for patients with various diseases. Journal of sport and health science. 2019 Sep 1;8(5):422-41.

Bendíková E, Marko M, Müller A, Bába ÉB. Effect of applied health-oriented exercises in physical and sport education on musculoskeletal system of female students. Acta Facultatis Educationis Physicae Universitatis Comenianae. 2018 Nov 1;58(2).

Kramer A. An overview of the beneficial effects of exercise on health and performance. Physical Exercise for Human Health. 2020:3-22.

Hartley C, Folland JP, Kerslake R, Brooke‐Wavell K. High‐Impact Exercise Increased Femoral Neck Bone Density With No Adverse Effects on Imaging Markers of Knee Osteoarthritis in Postmenopausal Women. Journal of Bone and Mineral Research. 2020 Jan;35(1):53-63.

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Published

01/30/2024

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Section

Systematic Review and Meta-Analyses