Effects of Exercise on Cartilage Thickness and Chondrocytes Count: A Meta-Analysis of Pre-Clinical Randomized Controlled Trials Conducted on Rats

Exercise and Cartilage Health


  • Kiran Yameen Ziauddin University
  • Dr. Kevin Joseph Jerome Borges Ziauddin University
  • Dr. Amna Aamir Khan Ziauddin University
  • Dr. Syed Nudrat Nawaid Shah Ziauddin University


Exercises, Cartilage, Chondrocytes, Animal Physical Conditioning


Background: The evidence regarding the effects of exercises on cartilage is enormous, literature on improving cartilage thickness and chondrocytes number is limited. To determine the cumulative effects of exercises on cartilage thickness and chondrocytes number by combining results from different randomized controlled trials.

Methods: Using MeSH terms like "cartilage thicknesses", "exercises", "chondrocytes", and "physical training", among others, multiple searches are conducted on exercise-based management approaches on cartilage thicknesses using search engines like Google Scholar, PEDro, MEDLINE, Cochrane Library, EMBASE, and Web of Science.

Results: The risk of bias assessment was performed based on the guidelines of SYRCLE. The author-based judgment was performed on selection, performance, detection, attrition, reporting, and other biases. The quantitative analysis revealed that femoral cartilage thickness had increased in the exercise group (SMD=1.039, CI%= -0.64 to 2.72, p=0.225) while chondrocyte count had shown a mild increase in response to excises (SMD= -0.147, CI%= -2.161 to 1.866, p=0.883).

Conclusion: It has concluded that although exercises have a potential impact on cartilage morphology but it must be performed within adaptive threshold limits.

DOI: https://doi.org/10.59564/amrj/02.01/025

Author Biographies

Kiran Yameen, Ziauddin University

College of Physical Therapy, Faculty of Allied Health Sciences

Dr. Kevin Joseph Jerome Borges, Ziauddin University

Professor, Department of Neuroanatomy, Ziauddin Medical College

Dr. Amna Aamir Khan, Ziauddin University

Associate Professor, College of Physical Therapy, Faculty of Allied Health Sciences

Dr. Syed Nudrat Nawaid Shah, Ziauddin University

Associate Professor, Department of Anatomy, Ziauddin Medical College


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Systematic Review and Meta-Analyses