Rejuvenating Mobility: Impact of Concurrent Exercise on Functional Claudication Distance and vascular health among Patients with T2DM-associated PAD

Concurrent Exercise for T2DM-associated PAD Patients



Claudication Distance, Diabetic Vascular Complication, Peripheral Artery Disease, Type-2 Diabetes Mellitus, Vascular Quality of Life


Background: Globally, the diabetes epidemic has increased in the general population over the last few decades. Despite higher prevalence of Type-II DM, evidence about Diabetes-related vascular complications is scarce. Therefore, this study aims to effectively determine appropriate exercise training into the clinical settings; thereby reducing risk factors for T2DM-associated PAD patients.

Methods: At the Department of Rehabilitation Sciences of Dr. Ziauddin Hospital Karachi, a randomized, single-blinded, two-arm trial was conducted from July to September 2023. Using the sealed envelope approach, 80 patients with T2DM-associated PAD were recruited and randomly assigned into two groups: Group-A (n=40) and Group-B (n=40). For a period of 12 weeks, participants in Group-B performed Aerobic Training (AT), while Group-A participated in Concurrent Training (CT), 3 times a week. Functional Claudication Distance (FCD) and VascuQol-6 were measured pre and post 12 week intervention for measuring functional capacity and vascular health. 

Results: Findings revealed that CT training groups were significantly effective (p<0.000) at 95% CI in improving FCD and VascuQol-6 after 12 weeks. Subsequently, findings showed that CT group showed more significant improvement than AT in improving FCD (p=0.013, CT: pre: 203.33±1.78, post: 230.65±7.72, AT: pre: 203.08±2.2, post: 214.13±5.1) and VascuQol-6 (p=0.0001, CT: pre: 10.60±2.11, post: 19.88±1.24, AT: pre: 9.53±2, post: 14.33±1.97).

Conclusion: Patients' reported vascular health and FCD significantly improved by the CT than AT group. Thereby, CT appears to be an exceptionally beneficial therapeutic strategy for the management of Fontaine’s stage II a PAD associated with T2DM.


Author Biographies

Uroosa Amin, Ziauddin University

Lecturer, College of Physical Therapy, Faculty of Allied Health Sciences

Qurat-ul-Ain Adnan, Ziauddin University

Principal, College of Physical Therapy, Faculty of Allied Health Sciences

Tauseef Ahmad, Dr. Ziauddin Hospital

FCPS Medicine, FCPS Endocrinology



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